Ammonium sorption from landfill leachates using natural and modified zeolites: pre-tests for a novel application of the ion exchanger loop stripping process

Ammonium (NH4+) is a main constituent of landfill leachates (50–2200 mg L−1) which has to be removed prior to indirect (<200 mg L−1) or direct discharge (<10 mg L−1) during landfill operation and aftercare, i.e., for more than 100 years after the end of waste disposal. In this study, lab-scale experiments regarding the sorption of NH4+ from landfill leachates using natural and modified clinoptilolite (Ca0.5,Na,K)6(Al6Si30)O72·20H2O) were conducted to assess the applicability of the innovative ion exchanger loop stripping (ILS) process for ammonium recovery. Samples of 20 g clinoptilolite after different pre-treatments (Ca loading, Na loading, natural loading) were shaken with 500 mL of each leachate from ten Austrian landfills (75 mg L−1 < c(NH4+) < 2805 mg L−1; 7.7 < pH < 8.7) for 24 h. Between 13% and 61% of the dissolved NH4+ was adsorbed to the clinoptilolite, which remained stable during the experiment. In summary, our study indicates that the ILS process is highly promising with respect to NH4+ recovery from landfill leachates, but further research is needed to reach threshold values for direct discharge

FLEX: A Decisive Step Forward in NASA's Combustion Research Program

Stemming from the need to prevent, detect and suppress on-board spacecraft fires, the NASA microgravity combustion research program has grown to include fundamental research. From early experiment, we have known that flames behave differently in microgravity, and this environment would provide an ideal laboratory for refining many of the long held principals of combustion science. A microgravity environment can provide direct observation of phenomena that cannot be observed on Earth. Through the years, from precursor work performed in drop towers leading to experiments on the International Space Station (ISS), discoveries have been made about the nature of combustion in low gravity environments. These discoveries have uncovered new phenomena and shed a light on many of the fundamental phenomena that drive combustion processes. This paper discusses the NASA microgravity combustion research program taking place in the ISS Combustion Integrated Rack, its various current and planned experiments, and the early results from the Flame Extinguishment (FLEX) Experiment

Index lesion contouring on prostate MRI for targeted MRI/US fusion biopsy - Evaluation of mismatch between radiologists and urologists

PURPOSE: Mistargeting of focal lesions due to inaccurate segmentations can lead to false-negative findings on MRI-guided targeted biopsies. The purpose of this retrospective study was to examine inter-reader agreement of prostate index lesion segmentations from actual biopsy data between urologists and radiologists. METHOD: Consecutive patients undergoing transperineal MRI-targeted prostate biopsy for PI-RADS 3-5 lesions between January 2020 and December 2021 were included. Agreement between segmentations on T2w-images between urologists and radiologists was assessed with Dice similarity coefficient (DSC) and 95 % Hausdorff distance (95 % HD). Differences in similarity scores were compared using Wilcoxon test. Differences depending on lesion features (size, zonal location, PI-RADS scores, lesion distinctness) were tested with Mann-Whitney U test. Correlation with prostate signal-intensity homogeneity score (PSHS) and lesion size was tested with Spearman's rank correlation. RESULTS: Ninety-three patients (mean age 64.9 ± 7.1y, median serum PSA 6.5 [4.33-10.00]) were included. Mean similarity scores were statistically significantly lower between urologists and radiologists compared to radiologists only (DSC 0.41 ± 0.24 vs. 0.59 ± 0.23, p < 0.01; 95 %HD 6.38 ± 5.45 mm vs. 4.47 ± 4.12 mm, p < 0.01). There was a moderate and strong positive correlation between DSC scores and lesion size for segmentations from urologists and radiologists (ρ = 0.331, p = 0.002) and radiologists only (ρ = 0.501, p < 0.001). Similarity scores were worse in lesions ≤ 10 mm while other lesion features did not significantly influence similarity scores. CONCLUSION: There is significant mismatch of prostate index lesion segmentations between urologists and radiologists. Segmentation agreement positively correlates with lesion size. PI-RADS scores, zonal location, lesion distinctness, and PSHS show no significant impact on segmentation agreement. These findings could underpin benefits of perilesional biopsies

Der Abklärungsprozess in der Invalidenversicherung bei Rentenentscheiden : Prozesse, Akteure, Wirkungen

Forschungsbericht Nr. 4/1

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

The absence of phytoestrogens in the diet during pregnancy has been reported to result in obesity later in adulthood. We investigated whether phytoestrogen withdrawal in adult life could alter the hypothalamic signals that regulate food intake and affect body weight and glucose homeostasis. Male Wistar rats fed from conception to adulthood with a high phytoestrogen diet were submitted to phytoestrogen withdrawal by feeding a low phytoestrogen diet, or a high phytoestrogen-high fat diet. Withdrawal of dietary phytoestrogens increased body weight, adiposity and energy intake through an orexigenic hypothalamic response characterized by upregulation of AGRP and downregulation of POMC. This was associated with elevated leptin and T4, reduced TSH, testosterone and estradiol, and diminished hypothalamic ERα expression, concomitant with alterations in glucose tolerance. Removing dietary phytoestrogens caused manifestations of obesity and diabetes that were more pronounced than those induced by the high phytoestrogen-high fat diet intake

Imaging features of COVID-19-associated secondary sclerosing cholangitis on magnetic resonance cholangiopancreatography: a retrospective analysis

Background: Despite emerging reports of secondary sclerosing cholangitis (SSC) in critically ill COVID-19 patients little is known about its imaging findings. It presents as delayed progressive cholestatic liver injury with risk of progression to cirrhosis. Diagnosis cannot be made based on clinical presentation and laboratory markers alone. Magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography (MRCP) can aid in the diagnosis. The aim of this study was to describe MRI/MRCP imaging features of COVID-19-associated SSC. Results: Seventeen patients (mean age 60.5 years, 15 male) who underwent MRI/MRCP were included. All had been admitted to intensive care unit (ICU) (median duration of ICU stay 10 weeks, range, 2-28 weeks) and developed acute respiratory distress syndrome requiring mechanical ventilation. On imaging, all patients had intrahepatic bile duct strictures and 10 (58.8%) had associated upstream dilatation. Intrahepatic bile duct beading was seen in 14 cases (82.3%). Only one patient (5.9%) had extrahepatic bile duct stricturing. Patchy arterial phase hyperenhancement and high signal on T2- and diffusion-weighted images were seen in 7 cases (53.8%) and 9 cases (52.9%), respectively. Biliary casts were seen in 2 cases (11.8%). Periportal lymphadenopathy and vascular complications were not seen. Conclusion: On MRI/MRCP, COVID-19-associated SSC presents with multiple intrahepatic bile duct strictures with or without upstream dilatation and intrahepatic bile duct beading. Surrounding hepatic parenchymal changes including alterations in enhancement and T2 signal are common. The extrahepatic biliary tree was typically spared and periportal lymphadenopathy was missing in all patients. Keywords: COVID-19; Cholangiopancreatography; Cholangitis; Magnetic resonance; Sclerosin

Demonstrating Reduced Gravity

A miniature drop tower, Reduced-Gravity Demonstrator is developed to illustrate the effects of gravity on a variety of phenomena including the way fluids flow, flames burn, and mechanical systems (such as pendulum) behave. A schematic and description of the demonstrator and payloads are given, followed by suggestions for how one can build his (her) own

An application of physical flexibility and software reconfigurability for the automation of battery module assembly

Batteries are a strategic technology to decarbonize conventional automotive powertrains and enable energy policy turnaround from fossil fuels to renewable energy. The demand for battery packs is rising, but they remain unable to compete with conventional technologies, primarily due to higher costs. Major sources of cost remain in manufacturing and assembly. These costs can be attributed to a need for high product quality, material handling complexity, uncertain and fluctuating production volumes, and an unpredictable breadth of product variants. This research paper applies the paradigms of flexibility from a mechanical engineering perspective, and reconfigurability from a software perspective to form a holistic, integrated manufacturing solution to better realize product variants. This allows manufacturers to de-risk investment as there is increased confidence that a facility can meet new requirements with reduced effort, and also shows how part of the vision of Industry 4.0 associated with the integration and exploitation of data can be fulfilled. A functional decomposition of battery packs is used to develop a foundational understanding of how changes in customer requirements can result in physical product changes. A Product, Process, and Resource (PPR) methodology is employed to link physical product characteristics to physical and logical characteristics of resources. This mapping is leveraged to enable the design of a gripper with focused flexibility by the Institute for Machine Tools and Industrial Management (iwb) at the Technical University of Munich, as it is acknowledged that mechanical changes are challenging to realize within industrial manufacturing facilities. Reconfigurability is realised through exploitation of data integration across the PPR domains, through the extension of the capabilities of a non-commercial virtual engineering toolset developed by the Automation Systems Group at the University of Warwick. The work shows an “end-to-end” approach that practically demonstrates the application of the flexibility and reconfigurability paradigms within an industrial engineering context